How exercise stalls cancer growth through the immune system

People with cancer who exercise regularly are better diagnosed than inactive patients. Now, researchers at the Carolinian Institute in Sweden have found a possible explanation for why exercise helps cancer growth in mice: physical activity alters the metabolism of toxicity T cells of the immune system and thus cancer. Improves their ability to attack cells. The study is published in the journal E-Life.

Randall Johnson, professor of cell and molecular biology at the Karolinska Institute, says that “behind the positive effects of exercise, organisms can provide new insights into how the body maintains health and designs and improves cancer treatment.” I help us The same author of the study.

Previous research has shown that physical activity can prevent unhealthiness as well as improve the diagnosis of various diseases, including various forms of cancer. Exactly how exercise works against cancer has its protective effects, however, it is not yet known, especially when it comes to biological mechanisms. One punishable explanation is that physical activity activates the immune system and thus strengthens the body’s ability to prevent and stop the growth of cancer.

In this study, researchers at the Karolinska Institute expanded on this speculation by examining how the immune system’s toxicity T cells, which are specialized in killing cancer cells, respond to exercise.

They divided the mice with the cancer into two groups and allowed one group to exercise regularly in one wheel while the other remained inactive. The results show that trained animals have slower cancer growth and a lower mortality rate than untrained ones.

Next, the researchers examined the importance of cytotoxic T cells by injecting antibodies that kill these T cells in both trained and untrained mice. Antibodies have been shown to have a positive effect on both the growth and survival of cancer, which researchers say demonstrates the importance of these T cells in controlling cancer.

The researchers also transmitted cytotoxic T cells to trained mice without trained tumors, which improved their chances compared to those who received cells from these trained animals.

To assess how exercise affected cancer growth, researchers isolated T cells, blood and tissue samples after training sessions and measured normal metabolites that are produced in muscle and High levels of plasma are released during labor. Some of these metabolites, such as lactate, alter the metabolism of T cells and increase their activity. The researchers also found that T cells were isolated from used animals, showing a mutated mutation from resting animals to T cells.

In addition, the researchers examined how these metabolites change in humans in response to exercise. After 30 minutes of brisk cycling, they took blood samples from eight healthy men and found that the same trained metabolites were released into humans.

“Our research shows that exercise affects the production of a number of molecules and metabolites that activate cancer-fighting immune cells and inhibit cancer growth,” said Helen, a senior researcher in the Department of Laboratory Medicine at the Karolinska Institute. Rehnquist and the first author of this study say. “We hope that these findings will help us to better understand how our lifestyle affects our immune system and the development of new hypnotherapy against cancer.”

Researchers have received funding from the Nutt and Ellis Wallen berg Foundation, the Swedish Research Council, the Swedish Cancer Society, the Swedish Childhood Cancer Foundation, the Swedish Society of Medicine, Cancer Research UK and the Welcome Trust.

 

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