A recent study by a research team led by Florian Kefer of the Madonna Vienna Division of Endocrinology and Metabolism found that high cold temperatures increase vitamin A levels in humans and mice. This helps convert “bad” white adipose tissue into “good brown” brown adipose tissue, which stimulates fat burning and heat generation.
This “fat conversion” usually occurs with increasing energy consumption and is therefore considered a promising approach to the development of novel obesity treatments. The study is now published in the journal Molecular Metabolism.
In humans and mammals, at least two types of fatty depots can be considered, white and brown adipose tissue. During the development of obesity, more calories are stored mainly in white fat. In contrast, brown fat burns energy and produces heat.
In humans, more than 90% of the body’s fat deposits are white, usually located on the abdomen, lower and upper thighs. Converting white to brown fat can be a new treatment for weight gain and obesity.
A research team led by Florian Kefer of Endocrinology and Metabolism at the Department of Medicine III in Madonna, Vienna, has now shown that moderate to cold use can increase the levels of vitamin A and its blood transporter, retinol-binding protein, in humans and mice. The level increases.
Most of the vitamin A’s reserves are stored in the liver, and exposure to cold can lead to redistribution of vitamin A toward the aging tissue. The cold-affected increase in vitamin A has resulted in the conversion of white fat into brown fat (“browning”), which has a higher fat burning rate.
When Kefer and his team inhibited vitamin A transporter “retinol-binding protein” in mice through genetic manipulation, the cold mediated increase in vitamin A and the “browning” of white fat were eliminated: “As a result In, fat oxidation kefir explains, and heat production was disrupted so that mice would not be able to protect themselves from the cold.
In contrast, the addition of vitamin A to human white fat cells increased metabolic activity and energy. As consumption increases, so do the characteristics of brown fat cells.
“Our results show that vitamin A plays an important role in adipose tissue function and affects global energy metabolism. However, if this is not recommended, it is important to consume extra amounts of vitamin A.
There is no argument, because it is necessary to have vitamin A. Medwani Vienna explains the researcher, “Transferred to the right cells at the right time. “We’ve discovered a new way for Vitamin A to regulate lipid combustion and heat generation in cold conditions. Exploit
Scientists from Harvard University, Boston and Rogers University, New Jersey were also involved in the study. The study was funded by the Austrian Science Fund (FWF), the Vienna Science and Technology Fund (WWTF) and the Austrian Diabetes Society Research Fund.